Endocrine Abstracts

Inadequate wound repair, observed in 15% of diabetics, leads to a chronic wound phenotype and is the leading cause of non-traumatic amputation in the developed world today. Injury induces recruitment of bone marrow-derived cells (BMDCs) to the wound in response to chemoattactant signals, which then contribute to the repair and regeneration process, initially through their role in the inflammatory response. Both granulocytes and monocytes are fundamental at this early stage, bu...